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review-article
Publication date (Electronic): 20 January 2022
Journal: Revista Clinica Espanola
Publisher: Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI).
Keywords: Long COVID, Post-COVID syndrome, Post-acute COVID-19, Long COVID haulers, COVID persistente, Síndrome COVID-19 prolongado, Síndrome pos-COVID, Síndrome pos-COVID-19 agudo
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Infection with the new SARS-CoV-2 coronavirus has reached pandemic proportions, with a very high death toll worldwide. Despite the scientific community's strenuous efforts to address this disease in its acute phase, as well as in prevention through the development of vaccines in record time, there remains another important workhorse: understanding and treating the persistence of symptoms beyond the acute phase, the so-called protracted COVID-19 syndrome or persistent COVID. These persistent manifestations affect several organs and systems and may depend on both the pathogenic mechanisms of the virus and the pathophysiological response of the patient. One year after the onset of this pandemic, there is an urgent need to address this situation from a comprehensive approach. La infección por el nuevo coronavirus SARS-CoV-2 ha alcanzado proporciones de pandemia, con un número de muertes muy elevado en todo el mundo. A pesar del esfuerzo ímprobo desarrollado por la comunidad científica para abordar esta enfermedad en su fase aguda, así como en la prevención mediante la creación de vacunas en tiempo récord, aún queda otro caballo de batalla importante: comprender y tratar la persistencia de síntomas más allá de la fase aguda, el llamado «síndrome COVID-19 prolongado» o «COVID persistente». Estas manifestaciones persistentes afectan a varios órganos y sistemas y podrían depender tanto de los mecanismos patogénicos del virus como de la respuesta fisiopatológica del paciente. Un año después del inicio de esta pandemia es una necesidad urgente abordar esta situación desde un enfoque integral. Abstract
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Evolution of antibody immunity to SARS-CoV-2
Christian Gaebler, Zijun Wang, Julio C C Lorenzi … (2021)
Severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) has infected 78million individuals and is responsible for over 1.7million deaths to date. Infection is associated with the development of variable levels of antibodies with neutralizing activity, which can protect against infection in animal models1,2. Antibody levels decrease with time, but, to our knowledge, the nature and quality of the memory Bcells that would be required to produce antibodies upon reinfection has not been examined. Here we report on the humoral memory response in a cohort of 87individuals assessed at 1.3 and 6.2months after infection with SARS-CoV-2. We find that titres of IgM and IgG antibodies against the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 decrease significantly over this time period, with IgA being less affected. Concurrently, neutralizing activity in plasma decreases by fivefold in pseudotype virus assays. By contrast, the number of RBD-specific memory Bcells remains unchanged at 6.2months after infection. Memory Bcells display clonal turnover after 6.2months, and the antibodies that they express have greater somatic hypermutation, resistance to RBD mutations and increased potency, indicative of continued evolution of the humoral response. Immunofluorescence and PCR analyses of intestinal biopsies obtained from asymptomatic individuals at 4months after the onset of coronavirus disease2019 (COVID-19) revealed the persistence of SARS-CoV-2 nucleic acids and immunoreactivity in the small bowel of 7 out of 14individuals. We conclude that the memory Bcell response to SARS-CoV-2 evolves between 1.3 and 6.2months after infection in a manner that is consistent with antigen persistence.
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One-year outcomes in survivors of the acute respiratory distress syndrome.
Margaret Herridge, Angela Cheung, Catherine Tansey … (2003)
As more patients survive the acute respiratory distress syndrome, an understanding of the long-term outcomes of this condition is needed. We evaluated 109 survivors of the acute respiratory distress syndrome 3, 6, and 12 months after discharge from the intensive care unit. At each visit, patients were interviewed and underwent a physical examination, pulmonary-function testing, a six-minute-walk test, and a quality-of-life evaluation. Patients who survived the acute respiratory distress syndrome were young (median age, 45 years) and severely ill (median Acute Physiology, Age, and Chronic Health Evaluation score, 23) and had a long stay in the intensive care unit (median, 25 days). Patients had lost 18 percent of their base-line body weight by the time they were discharged from the intensive care unit and stated that muscle weakness and fatigue were the reasons for their functional limitation. Lung volume and spirometric measurements were normal by 6 months, but carbon monoxide diffusion capacity remained low throughout the 12-month follow-up. No patients required supplemental oxygen at 12 months, but 6 percent of patients had arterial oxygen saturation values below 88 percent during exercise. The median score for the physical role domain of the Medical Outcomes Study 36-item Short-Form General Health Survey (a health-related quality-of-life measure) increased from 0 at 3 months to 25 at 12 months (score in the normal population, 84). The distance walked in six minutes increased from a median of 281 m at 3 months to 422 m at 12 months; all values were lower than predicted. The absence of systemic corticosteroid treatment, the absence of illness acquired during the intensive care unit stay, and rapid resolution of lung injury and multiorgan dysfunction were associated with better functional status during the one-year follow-up. Survivors of the acute respiratory distress syndrome have persistent functional disability one year after discharge from the intensive care unit. Most patients have extrapulmonary conditions, with muscle wasting and weakness being most prominent. Copyright 2003 Massachusetts Medical Society
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Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study
Harvey Moldofsky, John Patcai (2011)
Background The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood. Methods Sleep physiology, somatic and mood symptoms of 22 Toronto subjects, 21 of whom were healthcare workers, (19 females, 3 males, mean age 46.29 yrs.+/- 11.02) who remained unable to return to their former occupation (mean 19.8 months, range: 13 to 36 months following SARS) were compared to 7 healthy female subjects. Because of their clinical similarities to patients with fibromyalgia syndrome (FMS) these post-SARS subjects were similarly compared to 21 drug free female patients, (mean age 42.4 +/- 11.8 yrs.) who fulfilled criteria for fibromyalgia. Results Chronic post-SARS is characterized by persistent fatigue, diffuse myalgia, weakness, depression, and nonrestorative sleep with associated REM-related apneas/hypopneas, an elevated sleep EEG cyclical alternating pattern, and alpha EEG sleep anomaly. Post- SARS patients had symptoms of pre and post-sleep fatigue and post sleep sleepiness that were similar to the symptoms of patients with FMS, and similar to symptoms of patients with chronic fatigue syndrome. Both post-SARS and FMS groups had sleep instability as indicated by the high sleep EEG cyclical alternating pattern rate. The post-SARS group had a lower rating of the alpha EEG sleep anomaly as compared to the FMS patients. The post-SARS group also reported less pre-sleep and post-sleep musculoskeletal pain symptoms. Conclusions The clinical and sleep features of chronic post-SARS form a syndrome of chronic fatigue, pain, weakness, depression and sleep disturbance, which overlaps with the clinical and sleep features of FMS and chronic fatigue syndrome.
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Journal
Journal ID (nlm-ta): Rev Clin Esp (Barc)
Journal ID (iso-abbrev): Rev Clin Esp (Barc)
Title: Revista Clinica Espanola
Publisher: Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI).
ISSN (Electronic): 2254-8874
Publication date PMC-release: 20 January 2022
Publication date (Electronic): 20 January 2022
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Author notes
Article
Publisher Item ID: S2254-8874(22)00001-7
DOI: 10.1016/j.rceng.2021.09.004
PMC ID: 8769880
SO-VID: 9bb1a6a4-b411-4fd9-bc7a-b1fed09e54c9
Copyright © © 2021 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.
License:
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
History
Date received : 10 May 2021
Date accepted : 17 September 2021
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Subject: Review
Keywords: long covid,post-covid syndrome,post-acute covid-19,long covid haulers,covid persistente,síndrome covid-19 prolongado,síndrome pos-covid,síndrome pos-covid-19 agudo
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Keywords: long covid, post-covid syndrome, post-acute covid-19, long covid haulers, covid persistente, síndrome covid-19 prolongado, síndrome pos-covid, síndrome pos-covid-19 agudo
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